Main article: Anti-neurofascin demyelinating diseases

Д¬IDP has been associated with diabetes mellitus, HIV infection, and paraproteinemias. Application of the present research criteria to routine clinical practice often misses the diagnosis in a majority of patients, and patients are often left untreated despite progression of their disease. Although there are stringent research criteria for selecting patients for clinical trials, there are no generally agreed-upon clinical diagnostic criteria for CIDP due to its different presentations in symptoms and objective data.

There is a lack of awareness and treatment of CIDP. Despite these limitations, early diagnosis and treatment is favoured in preventing irreversible axonal loss and improving functional recovery. CIDP is extremely rare but under-recognized and under-treated due to its heterogeneous presentation (both clinical and electrophysiological) and the limitations of clinical, serologic, and electrophysiologic diagnostic criteria. Typical early symptoms are 'tingling' (sort of electrified vibration or paresthesia) or numbness in the extremities, frequent (night) leg cramps, loss of reflexes (in knees), muscle fasciculations, 'vibration' feelings, loss of balance, general muscle cramping and nerve pain. Causes Structure of a typical neuronД¬hronic inflammatory demyelinating polyneuropathy (or polyradiculoneuropathy) is considered an autoimmune disorder destroying myelin, the protective covering of the nerves. These cases seem to be related to the presence of anti-neurofascin autoantibodies. It is termed 'combined central and peripheral demyelination' (CCPD) and is special because it belongs at the same time to the CDIP syndrome and to the multiple sclerosis spectrum.

A variant with CNS involvement named combined central and peripheral demyelination (CCPD) Д¬urrently there is one special variant in which the CNS is also affected.

or MADSAM (multifocal acquired demyelinating sensory and motor neuropathy)

An asymmetrical variant of CIDP is known as Lewis-Sumner Syndrome.

2.2 Autoantibodies of the IgG3 Subclass in CIDP.

2.1 Variants with paranodal autoantibodies.

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